This porn video tag indicates a scene involving a transgender individual (often referred to as "shemale" or "TS," where TS stands for "transsexual") engaging in sexual activities with one or more male partners. The term "with-male" specifies that there is at least one male participant present in the scene, which distinguishes it from scenes involving only transgender individuals ("trans-only"). This tag is aimed towards an adult audience who are specifically interested in watching porn videos featuring this particular combination of sexual partners and gender identities.